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Development of translational models for intervertebral disc degeneration using a comparative approach for canine and human patients
(University of Missouri--Columbia, 2020)
characteristics of key disease phenotypes. Using biomarkers associated with inflammation and degradation, IVD health and disease were characterized for the two species. Taken together, this body of work suggests that CD and NCD dogs demonstrate distinctly...
Genetic and microbiota-mediated phenotype variability in the min mouse model of human colorectal cancer
(University of Missouri--Columbia, 2019)
Complex diseases develop as a result of genetic predisposition and environmental factors that determine individual risk. Environmental factors such as geographical location, diet, and lifestyle choices shape the gut microbiota (GM), a dynamic...
Epidemiology of non-aureus staphylococcal mastitis in dairy goats
(University of Missouri--Columbia, 2018)
. epidermidis, S. caprae, S. simulans, and Staphylococcus xylosus were considered as possible udderadapted pathogens, whereas Staphylococcus arlettae, Staphylococcus equorum, and Staphylococcus lentus might be considered either opportunistic or environmental...
Plastic and evolved morphological responses of the hind limb skeleton to mechanical loading in mice
(University of Missouri--Columbia, 2018)
[ACCESS RESTRICTED TO THE UNIVERSITY OF MISSOURI AT AUTHOR'S REQUEST.] Skeletal morphology is determined by a combination of genetic background and phenotypic plasticity induced by mechanical loading. The changes in limb ...
Reflux, aspiration and respiratory disease in dogs : clinical consideration and advances in aerodigestive diagnostics
(University of Missouri--Columbia, 2019)
The aspiration of gastric contents into the respiratory tract has been associated with the development and progression of multiple respiratory diseases in humans. In veterinary medicine the term "aspiration" is considered ...
Ultrastructural damages in the brain induced by low-intensity primary blast wave : a transmission electron microscopy study on mild traumatic brain injury
(University of Missouri--Columbia, 2018)
[ACCESS RESTRICTED TO THE UNIVERSITY OF MISSOURI AT AUTHOR'S REQUEST.] Explosive blast-induced mild traumatic brain injury (mTBI), a "signature wound" of recent military conflicts, commonly affects Service Members. While ...
Improving ligament tissue scaffold with the use of genipin and gold nanoparticles
(University of Missouri--Columbia, 2020)
Decellularized tissue is used for a wide array of tissue injuries with tendon and ligament repair being among the most common. However, despite their frequent use there is concern over the lengthy inflammatory period and ...
Defining recurrent laryngeal nerve injury in a mouse model for regenerative therapeutic investigations
(University of Missouri--Columbia, 2019)
Injury of the recurrent laryngeal nerve (RLN), a branch of the vagus nerve, results in ipsilateral vocal fold (VF) paralysis that contributes to dysphagia, dysphonia, and dyspnea (i.e., swallow, vocal, and respiratory ...